The Origins and Consequences of Localized and Global Somatic Hypermutation
F. Yousif, S. Prokopec, R. X. Sun, F. Fan, C. M. Lalansingh, E. Drysdale, D. H. Park, L. Szyca, PCAWG Network, P. C. Boutros
This study identifies genes driving localized and global hypermutation in tumors and finds that kataegis (localized mutation rainstorms) are associated with specific genetic alterations and patient outcomes.
bioRxiv · Jun 29, 2018 · PreprintCancer Biology