PIK-75 suppresses an SREBP-centred sterol programme in PIK3CA-altered small-cell lung cancer cells, but attribution to p110α remains unresolved
Aref Movaqar, Atieh Yaghoubi, S.A. Rahim Rezee
The paper evaluates the effects of PIK3CA-targeted inhibitors on gene expression in SCLC cells, finding PIK-75 suppresses SREBP-related lipid synthesis genes but its mechanism remains unclear.
bioRxiv · Oct 9, 2026 · PreprintCancer Biology