When can whole-genome SNP heritability be reliably estimated from summary statistics?
Benjamin K. Pham, Samuel Davenport, David Azriel, Armin Schwartzman
This study argues that fixing the intercept in LDSC improves SNP heritability estimation by reducing bias and variance, but LDSC remains biased under population stratification.
bioRxiv · May 16, 2026 · PreprintGenetics