Systematic Pan-cancer Functional Inference and Validation of Hyper, Hypo and Neomorphic Mutations
Somnath Tagore, Samuel Tsang, Gordon Brent Mills, Andrea Califano
The paper functionally characterizes 577,866 non-recurrent mutations across TCGA cohorts by analyzing TF activity, identifying neomorphic and mimicry mutations, and validating them with knock-in assays.
bioRxiv · Apr 29, 2023 · PreprintSystems Biology