Directional Gene-Level Concordance and Methodological Constraints in Blood Transcriptomic and DNA Methylation Studies of Parkinson's Disease
Chiragh Dewan, Inayat Chauhan, Kanika Sharma, Sangeeta Sharma, Rupinderjeet Kaur
This study evaluates reproducibility of transcriptomic and DNA methylation findings in Parkinson's disease across multiple cohorts and analytical pipelines, finding directional consistency is more reliable than gene-identity overlap.
bioRxiv · May 20, 2026 · PreprintNeuroscience