Sequential acquisition of virulence and fluoroquinolone resistance has shaped the evolution of Escherichia coli ST131
Nouri L Ben Zakour, Areej S Alsheikh-Hussain, Melinda M Ashcroft, Nguyen Thi Khanh Nhu, Leah W Roberts, Mitchell Stanton-Cook, Mark A Schembri, Scott A Beatson
This study reconstructs the evolutionary history of Escherichia coli ST131, showing that fluoroquinolone resistance emerged after virulence gene acquisition and coincided with the first clinical use of fluoroquinolone in 1986.
bioRxiv · Feb 9, 2016Microbiology