An Entropy-based Directed Random Walk for Pathway Activity Inference Using Topological Importance and Gene Interactions
Tay Xin Hui, Tole Sutikno, Shahreen binti Kasim, Mohd Farhan Md Fudzee, Shahliza Abd Halim, rohayanti binti hassan, Seah Choon Sen
This paper introduces an entropy-based directed random walk method to improve pathway activity inference by incorporating gene interactions and topological importance, showing better sensitivity and accuracy in cancer classification.
bioRxiv · Nov 5, 2021 · PreprintBioinformatics