Minimal Data, Maximal Insight (MDMI): A Structure-guided Pipeline for Discovering Functional Alternatives in Peptide-Protein Interfaces
Pouriya Bayat, Spencer James Perkins, Sebastian Clancy, Sahil Swapnesh Patel, Richard Fei Yin, Krištof Bozovičar, Serena Singh, Suman Shrestha, Zain Moustafa, Riham Zayani, Idorenyin A. Iwe, Sepehr Bayat, Paul Kelly, Justin R. J. Vigar, Vivan Yuna White, , Keith Pardee
MDMI is a structure-guided pipeline that designs functional peptide variants from minimal data, achieving high accuracy and discovering divergent sequences with measurable activity.
bioRxiv · Jul 14, 2026 · PreprintSynthetic Biology