Meta-analyses of the NEPTUNE dataset related to high and low risk FSGS and cellular APOL1 models identifies Calcium signalling, mTOR signaling and inflammation-associated pathways as operative in APOL1-mediated kidney disease.
Wasco Wruck, Chantelle Thimm, Tama Amin, Maria-Darline Somoano Sanchez, Sejla Pulo, James Adjaye
The paper identifies gene expression signatures and pathways associated with APOL1-mediated kidney disease using transcriptome data and cellular models.
bioRxiv · Jul 31, 2026 · PreprintMolecular Biology