Antiandrogen Flutamide-Induced Restoration of miR-449 Expression Mitigates Functional Biomarkers Associated with Ovarian Cancer Risk
Xia Wang, Ho-Hyung Woo, Michele Wei, Steven J. Gibson, Mitzi Miranda, Demaretta S. Rush, Janiel M. Cragun, Wenxin Zheng, Guang Yao, Setsuko K. Chambers
This study shows flutamide restores miR-449 expression in high-risk ovarian tissues, reducing AR and CSF1R levels and inhibiting cancer cell migration and proliferation.
medRxiv · Feb 26, 2024 · PreprintGenetic & Genomic Medicine