Identification of novel myelodysplastic syndromes prognostic subgroups by integration of inflammation, cell-type composition, and immune signatures in the bone marrow
Sıla Gerlevik, Nogayhan Seymen, Shan Hama, Warisha Mumtaz, Ian Richard Thompson, Seyed R Jalili, Deniz Ece Kaya, Alfredo Iacoangeli, Andrea Pellagatti, Jacqueline Boultwood, Giorgio Napolitani, Ghulam Jeelani Mufti, Mohammad Mahdi Karimi
The paper integrates inflammation, cell-type composition, and immune signatures in MDS to identify prognostic subgroups using MOFA, finding that high inflammation correlates with better prognosis while SRSF2 mutations are linked to poor outcomes.
eLife · Sep 5, 2024Peer-reviewedGenomics