Reconstructing subclonal composition and evolution from whole genome sequencing of tumors
Amit G. Deshwar, Shankar Vembu, Christina K. Yung, Gun Ho Jang, Lincoln Stein, Quaid Morris
This paper introduces PhyloWGS, a method for subclonal reconstruction from whole genome sequencing data, showing it can accurately recover subclonal composition, genotype, and phylogeny using both SSMs and CNVs.
Genome Biology · Feb 13, 2015Peer-reviewedBioinformatics