SPARKLE: evidence-constrained correction of local RNA leakage in high-resolution spatial transcriptomics
Shuai Wang, Bolin Zhu, Shanyou Li, Xiaoyu Wei
SPARKLE corrects local RNA leakage in spatial transcriptomics by using spatial evidence within each sample, improving cell-type localization and communication inference.
bioRxiv · Sep 8, 2026 · PreprintBioinformatics