CLOCK Mediates Delay in Cardiac Myofibroblast Formation and Attenuates Progression of Myocardial Fibrosis through Inhibition of Smad 3 Transcriptional Activity
Yongqiao Zhou, Minqi Liao, Lihua Chen, Yongzhao Yao, Zhichao Huang, Yanhua Yang, Shaohui Su, Guangzhu Liang, Zhihao Wu, Shumin Ouyang, Suxia Guo
This study shows CLOCK inhibits cardiac myofibroblast formation and reduces myocardial fibrosis by suppressing Smad3 transcriptional activity.
bioRxiv · Aug 27, 2023 · PreprintMolecular Biology