Resolving Heterogeneity in Major Depression: Overcoupling and Undercoupling Subtypes Exhibit Differential Treatment Response and Molecular Pathways
Huaijin Gao, Yihan Ma, Rui Qian, Tao Jin, Baorong Gu, Bowen Qiu, Shaoyong Ye, Manli Huang, Dan Wu, Zhiyong Zhao
This study identifies two MDD subtypes based on morphological-functional coupling alterations, showing differential treatment response and molecular pathways.
bioRxiv · Nov 5, 2025 · PreprintNeuroscience