Harnessing Protein Language Model for Structure-Based Discovery of Highly Efficient and Robust PET Hydrolases
Banghao Wu, Bozitao Zhong, Lirong Zheng, Runye Huang, Shifeng Jiang, Mingchen Li, Liang Hong, Pan Tan
This paper uses a protein language model and structural representation tree to discover improved PET hydrolases, identifying KbPETase with higher thermal stability and degradation activity.
Nature Communications · Jul 5, 2025Peer-reviewedMolecular Biology