Spatiotemporal Patterns of Active Deformation Reveal Downregulation of Cell-Cell Adhesion in Patient-Derived Colorectal Cancer Organoids with BRAF Mutation
Shogo Nagai, Ryo Suzuki, Go Yamakawa, Akihisa Fukuda, Hiroshi Seno, Motomu Tanaka
This study shows that BRAF-mutated colorectal cancer organoids have reduced elasticity and increased viscosity, linked to decreased cell-cell adhesion and potential therapeutic implications.
bioRxiv · Mar 8, 2026 · PreprintBiophysics