A distinct subset of stem-cell memory is poised for the cytotoxicity program in CD4+ T cells in humans.
Raunak Kar, Shreya Sinha, Zainab Khatun, Anjali Sharma, Veena S. Patil
This study identifies a distinct stem-cell memory subset in CD4+ T cells that is pre-committed to a cytolytic program, showing similarities to CD8-CTLs and demonstrating the potential for generating long-lived cytotoxic CD4+ T cells.
Science Advances · Jan 7, 2026Peer-reviewedImmunology