Model-based analysis of response and resistance factors of cetuximab treatment in gastric cancer cell lines
Elba Raimúndez, Simone Keller, Gwen Zwingenberger, Karolin Ebert, Sabine Hug, Fabian Joachim Theis, Dieter Maier, Birgit Luber, Jan Hasenauer
This paper develops a mechanistic model of gastric cancer to study response and resistance factors for cetuximab treatment, showing it can predict responses to perturbations and identify causal differences between cell lines.
PLoS Computational Biology · Mar 2, 2020Peer-reviewedSystems Biology