Ultraslow water-mediated transmembrane interactions regulate the activation of A2A adenosine receptor
Yoonji Lee, Songmi Kim, Sun Choi, Changbong Hyeon
The paper uses molecular dynamics simulations to show that ultraslow water dynamics in the active state of A2A adenosine receptor are critical for GPCR activation.
bioRxiv · Aug 4, 2016Biophysics