Refining RDoC Using Individual-Level Task fMRI Factor Models RevealsReproducible and Clinically Relevant Brain-Wide Motifs
Shaun K.L. Quah, Saad Pirzada, Soren Madsen, Booil Jo, Lucina Q. Uddin, Jeanette A. Mumford, Deanna M. Barch, Ian H. Gotlib, Damien A. Fair, Russell Alan Poldrack, Manish Saggar
This paper validates data-driven factor models over RDoC-based models using fMRI and behavioral data, showing better reproducibility and clinical relevance across neural and behavioral domains.
bioRxiv · Oct 13, 2025 · PreprintNeuroscience