Author

Srinath Seshadri

Duke University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1

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Approach:deep learning· 1 Research Focus:protein design· 1 Assay:protein sequence· 1 Research Focus:sequence-to-function modeling· 1 Approach:statistical model· 1

Frequent Co-Authors

Agrim Babbar· 1 shared Ameya Kulkarni· 1 shared Kensuke NakamuraiD· 1 shared Nathaniel BlalockiD· 1 shared Philip A. RomeroiD· 1 shared Sarah A. FahlbergiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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6 top collaborators · 15 mutual co-author links

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1 shared paperBioengineering

Agrim Babbar

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1 paper

Recent·Most cited

Functional alignment of protein language models via reinforcement learning

Nathaniel Blalock, Srinath Seshadri, Kensuke Nakamura, Agrim Babbar, Sarah A. Fahlberg, Ameya Kulkarni, Philip A. Romero

This paper introduces RLXF, a framework that aligns protein language models with experimental functional goals, improving the generation of high-functioning protein variants.

Nature Communications · Sep 12, 2026Peer-reviewedBioengineering