Fundamentals on the Kinetic and Thermodynamic Analysis of Oligonucleotide DNA Hybridization by Surface Plasmon Resonance: A Guide for HIF1α Antisense Design.
Stephen Cornwell, Frank Podlaski, Kenny Wong, Brian McKittrick, Jae‐Hun Kim, William T. Windsor
This paper provides a guide for designing SPR experiments to analyze DNA oligonucleotide hybridization kinetics and thermodynamics, with applications to antisense oligonucleotide design.
bioRxiv · Oct 24, 2026 · PreprintBiochemistry