APOE ε4 defines a systemic immune endophenotype independent of clinical trajectory in amyotrophic lateral sclerosis
Artur Shvetcov, Shannon Thomson, Sterling Kwan, Terri G. Thompson, Jeffery D. Rothstein, Caitlin A. Finney
This study identifies an APOE ε4-associated systemic immune proteomic signature in ALS that predicts disease progression independently of clinical features.
bioRxiv · Feb 4, 2026 · PreprintNeuroscience