Designed architectural proteins that tune DNA looping in bacteria
D. H. Tse, N. A. Becker, R. T. Young, W. K. Olson, J. P. Peters, T. L. Schwab, K. J. Clark, L. J. Maher
The paper designs and tests artificial architectural proteins in bacteria to tune DNA looping, finding that TALE proteins inhibit looping by stiffening DNA while HMGB domains enhance looping by bending DNA.
bioRxiv · Jun 30, 2021Biochemistry