Adaptive landscape of protein variation in human exomes
R. Patel, M. D. Sanderford, T. R. Lanham, K. Tamura, A. Platt, B. S. Gilksberg, J. T. Dudley, L. B. Scheinfeldt, K. Xu, S. Kumar
The paper develops an Evolutionary Probability Approach (EPA) to identify candidate adaptive polymorphisms in human exomes, finding thousands of missense variants likely under beneficial selection.
bioRxiv · Mar 14, 2018Evolutionary Biology