Integrative genomics uncover mechanisms of renal medullary carcinoma transformation, microenvironment landscape and therapeutic vulnerabilities.
B. H. Vokshi, G. Davidson, A. Helleux, M. Rippinger, A. R. Haller, J. Gantzer, P. Baltzinger, J. Thouvenin, R. Bouarich, V. Manriquez, S. Zaidi, P. Msaouel, X. Su, H. Lang, T. Tricard, , G. G. Malouf
This study uses single-cell and multi-region sequencing to define RMC transformation, identify cell states, and uncover therapeutic vulnerabilities through transcriptional changes and microenvironment interactions.
bioRxiv · Sep 29, 2021 · PreprintCancer Biology