Genome-Wide Assessment of Pleiotropy Across >1000 Traits from Global Biobanks
Michael G. Levin, Satoshi Koyama, Jakob Woerner, David Y Zhang, Alexis Rodriguez, Tarak Nandi, Buu Minh Thanh Truong, Sarah A. Abramowitz, Hritvik Gupta, Himani Kamineni, Whitney Hornsby, Zilinghan Li, Taylor Cohron, Jennifer E. Huffman, Patrick T. Ellinor, , Pradeep Natarajan
The paper identifies pleiotropic loci across 1,167 traits using GWAS meta-analysis and shows they are enriched for functional annotations and improve polygenic score predictions.
medRxiv · Apr 18, 2025 · PreprintGenetic & Genomic Medicine