A propensity to hyperinsulinaemia underpins diet-induced diabetes in NODk mice
Matthew F. Waters, Ainy Hussain Hussain, Viviane Delghingaro‐Augusto, Muhammad Shamoon, Amita Bansal, Zhi-Ping Feng, T. Daniel Andrews, Tenzin Dagpo, Mark E. Koina, Jane Esther Dahlstrom, Christopher James Nolan
This study shows that male NODk mice develop severe type 2 diabetes with hyperinsulinaemia on a Western diet, while B10k mice are resistant, supporting hyperinsulinaemia as upstream in this diabetes subtype.
bioRxiv · Jul 21, 2026 · PreprintPhysiology