A single-cell eQTL atlas of the human cerebellum reveals vulnerability of oligodendrocytes in essential tremor
Charles-Etienne Castonguay, Farah Aboasali, Miranda Medeiros, Théodore Becret, Zoe Schmilovich, Anouar Khayachi, Alex H. Rajput, Patrick A. Dion, Guy Armand Rouleau
The paper constructs a single-cell eQTL atlas of the human cerebellum and identifies ET-associated variants linked to BACE2 downregulation in oligodendrocytes, suggesting demyelination and dysfunctional interactions.
bioRxiv · May 22, 2024 · PreprintGenomics