When do hybrid models help? Combining mechanistic modelling and machine learning to predict gene regulatory network dynamics
Ben Noordijk, Thijs van Loo, Milan van Hoek, Marcel J. T. Reinders, Aalt D. J. van Dijk, Monica L. García‐Gómez, Kirsten ten Tusscher, Dick de Ridder
This study investigates when combining mechanistic and machine learning models improves predictions of gene regulatory network dynamics using synthetic data.
bioRxiv · Oct 21, 2026 · PreprintBioinformatics