Active Learning Enables Efficient Directed Evolution of a Far-Red Fluorescent Protein with Minimal Experimental Data
Daniel V. Brown, Ryan Stanley Cross, Shiying Zhu, Thomas Hill, Chhon Ling Sok, Misty Rayna Jenkins, Marija Dramićanin, Rory J. Bowden
This paper uses active learning to improve a far-red fluorescent protein with fewer experiments, but performance varies between bacterial and mammalian cells.
bioRxiv · Aug 17, 2026 · PreprintSynthetic Biology