Author

Thomas J Hardcastle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Organism:non-human primate· 1

Frequent Co-Authors

Chris Jiggins· 1 shared James R Walters· 1 shared

Activity by Year

2015-2016 · peak 1/yr

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2 top collaborators · 1 mutual co-author link

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1 shared paperGenomics

Chris Jiggins

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2 papers

Recent·Most cited

Generalised empirical Bayesian methods for discovery of differential data in high-throughput biology

Thomas J Hardcastle

The paper introduces a generalized empirical Bayesian method for detecting differential behavior in high-throughput biological data, showing it can achieve equivalent or better performance than existing methods.

Bioinformatics · Jan 15, 2016Peer-reviewedBioinformatics

Sex chromosome dosage compensation in Heliconius butterflies: global yet still incomplete?

James R Walters, Thomas J Hardcastle, Chris Jiggins

This study investigates sex chromosome dosage compensation in Heliconius butterflies, finding incomplete compensation with a 5-20% male expression increase on the Z chromosome across tissues.

bioRxiv · Mar 19, 2015Genomics