Large-scale evaluation of proteomic and polygenic risk scores reveals complementary contributions to incident disease prediction
Jakob Woerner, Thomas M. Westbrook, Jaehyun Joo, Manu Shivakumar, Rasika Venkatesh, Tess Cherlin, Sang‐Hyuk Jung, Seokho Jeong, Damián Maseda, Michelle L. McKeague, Shwetank, Matei Ionita, Joost Wagenaar, Sarah A. Abramowitz, Anurag Verma, , Dokyoon Kim
The paper evaluates proteomic and polygenic risk scores for disease prediction, finding proteomic scores outperform polygenic scores in most traits and show temporal responsiveness.
medRxiv · Jul 10, 2025 · PreprintGenetic & Genomic Medicine