Capturing Multi-Scale Dynamics of Aortic Valve Calcification With a Coupled Fluid Structure and Systems Biology Model
Michael Quan, Tianyou Xie, Leonard A. Harris, Haoxiang Luo
The paper presents a coupled fluid-structure and systems biology model to simulate aortic valve calcification dynamics, showing fibrosis-induced stiffening accelerates calcification through altered biomechanical and biochemical pathways.
bioRxiv · Mar 19, 2026 · PreprintSystems Biology