A generalizable Cas9/sgRNA prediction model using machine transfer learning with small high-quality datasets
Dalton T. Ham, Tyler S. Browne, Pooja N. Banglorewala, Tyler L. Wilson, Richard K. Michael, Gregory Brian Gloor, David R. Edgell
The paper develops a transfer learning model, crisprHAL, to improve SpCas9/sgRNA activity prediction using small high-quality datasets.
Nature Communications · Sep 7, 2023Peer-reviewedBioinformatics