Differential Dynamic Behavior of Prefusion Spike Proteins of SARS Coronaviruses 1 and 2
V. Govind Kumar, D. S. Ogden, U. Isu, A. Polasa, J. Losey, M. Moradi
This study uses molecular dynamics simulations to compare the dynamic behavior of prefusion spike proteins in SARS-CoV-1 and SARS-CoV-2, finding that SARS-CoV-2's spike is more stable with a higher energy barrier for activation.
bioRxiv · Dec 25, 2020 · PreprintBiophysics