Comparative MD simulations and advanced analytics based studies on wild-type and hot-spot mutant A59G HRas
R. Joshi, N. Sharma, U. Sonavane
This study uses MD simulations and advanced analytics to compare wild-type and A59G mutant HRas, finding that the mutant lacks a pre-hydrolysis network, leading to a permanently active oncogenic state.
bioRxiv · Jun 4, 2020Biophysics