Directed differentiation of human pluripotent stem cells into articular cartilage reveals effects caused by absence of WISP3, the gene responsible for Progressive Pseudorheumatoid Arthropathy of Childhood
Chaochang Li, Mireia Alemany‐Ribes, Rosanne M. Raftery, Uzochi Nwoko, Matthew L. Warman, April M. Craft
This study differentiates WISP3-deficient and sufficient hPSCs into articular cartilage-like tissues, revealing transcriptomic and cellular differences linked to PPAC pathogenesis.
Annals of the Rheumatic Diseases · Sep 7, 2023Peer-reviewedGenetics