From Randomness to Recognition: Modeling the Evolution of DNA Sequence Information During SELEX
Varun Maher, Daniel R. Martin, David B. Spetzler, Zhan‐Gong Zhao, Heather A. O’Neill, Neal W. Woodbury
This paper uses NLP to model DNA sequence evolution during SELEX, showing that latent space representations correlate with binding specificity and can distinguish between enriched libraries for different targets.
bioRxiv · Mar 31, 2025 · PreprintBiochemistry