Organelle Aging Predicts Human Disease
Kejun Ying, Kyle KunHyung Roh, Kenneth L Chen, Veronica Augustina Bot, Daisy Yi Ding, Amelia Farinas, The Global Neurodegeneration Proteomics Consortium (GNPC), Carl Ma, Hamilton Se-Hwee Oh, Alina Isakova, Tony Wyss-Coray
The paper models subcellular aging across 10 organelles using proteomic data from 61,931 individuals and finds that premature organelle aging is associated with increased disease risk and mortality.
bioRxiv · Nov 3, 2026 · PreprintSystems Biology