Author

Vijayalakshmi Mahadevan

Institute of Bioinformatics

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Harsha Rani· 2 shared Dimple NotaniiD· 1 shared Mohit Kumar JollyiD· 1 shared Seemadri SubhadarshiniiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

4 top collaborators · 4 mutual co-author links

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2 shared papersGenomics

Harsha Rani

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2 papers

Recent·Most cited

Loss of tumour suppressor p53 rewires enhancer landscape and governs oncogenic progression

Harsha Rani, Dimple Notani, Vijayalakshmi Mahadevan

This paper shows that p53 loss in colorectal cancer increases enhancer activity, drives oncogenic pathways, and correlates with poor survival in p53-deficient tumors.

bioRxiv · Jul 28, 2025 · PreprintGenomics

Gain of Function p53 mutant R273H confers distinct methylation profiles and consequent partial or full EMT states to colon tumour

Harsha Rani, Seemadri Subhadarshini, Mohit Kumar Jolly, Vijayalakshmi Mahadevan

The paper analyzes methylation and transcriptomic data to show that p53 R273H mutation in colon cancer is linked to partial or full EMT states and metastasis.

bioRxiv · Jul 3, 2025 · PreprintBioinformatics