Comprehensive analysis of de novo variants across 2,497 orofacial cleft trios reveals novel genetic drivers of disease
Nehir Edibe Kurtas, Alba Sanchis‐Juan, Eren Shin, Sarah W. Curtis, Kelsey R. Robinson, Arthur S. Lee, Azeez Arisekola Alade, Xuefang Zhao, Jack M. Fu, Kimberly K. Diaz Perez, Lord Jephthah Joojo Gowans, Mekonen A. Eshete, WasiuL Adeyemo, Carmen J. Buxó, Carmencita D. Padilla, , Harrison Brand
This study identifies novel genetic drivers of orofacial clefts by analyzing de novo variants in 2,497 trios and integrating findings across subtypes and syndromic status.
medRxiv · May 24, 2026 · PreprintGenetic & Genomic Medicine