Deletion of adipocyte Sine Oculis Homeobox Homolog 1 prevents lipolysis and attenuates skin fibrosis.
Nancy E. Wareing, Tingting Mills, Scott D. Collum, Minghua Wu, Lucy Revercomb, Rene Girard, Marka A. Lyons, Brian A. Skaug, Weizhen Bi, Meer Akbar Ali, Haniyeh Koochak, Anthony R Flores, Yuntao Yang, Wenjin Jim Zheng, William R. Swindell, , Harry Karmouty‐Quintana
This study identifies SIX1 as a driver of dermal fibrosis in systemic sclerosis by linking its upregulation to adipocyte dysfunction and fibrotic gene expression.
bioRxiv · May 22, 2024 · PreprintMolecular Biology