Computational discovery of co-expressed antigens as dual targeting candidates for cancer therapy through bulk, single-cell, and spatial transcriptomics
Evgenii Chekalin, Shreya Paithankar, Rama Shankar, Jing Xing, Wenfeng Xu, Bin Chen
The paper develops a computational pipeline to identify bispecific antibody targets by integrating bulk, single-cell, and spatial transcriptomics data, finding GPC3 and MUC13 as promising candidates in hepatocellular carcinoma.
Bioinformatics Advances · Jan 1, 2024Peer-reviewedBioinformatics