SPARC Reveals Distinct Osteoclastogenesis-Associated Malignant States in Metastatic Osteosarcoma
Shiyi Wu, William Cameron Walker, Carolyn Martin, Jason Todd Yustein, Md. Abul Hassan Samee
SPARC improves trajectory inference by jointly modeling state progression and transitions between conditions, revealing osteoclastogenesis-associated malignant states in osteosarcoma metastasis.
bioRxiv · Jul 11, 2026 · PreprintBioinformatics