Loss of a subunit of vacuolar ATPase identifies unexpected biological signatures of reduced organelle acidification in vivo
Lore Pottie, Wouter Van Gool, Michiel Vanhooydonck, Franz‐Georg Hanisch, Geert Goeminne, Andreja Rajković, Paul J. Coucke, Patrick Yves Sips, Bert Louis Callewaert
This study shows that loss of atp6v1e1b in zebrafish causes multisystemic defects linked to reduced organelle acidification, revealing new biological impacts of v-ATPase dysfunction.
PLoS Genetics · Jun 18, 2021Peer-reviewedMolecular Biology