PPAR-γ/PCK1 metabolic pathway modulate synovitis and fibrosis in KOA rats
Junjie Wu, Xiaodi He, Lucheng Chen, Zhaolin Li, Ling Jie, Hao Xu, Yanwen Hu
This study identifies the PPAR-γ/PCK1 metabolic pathway as a regulator of synovitis and fibrosis in KOA rats, showing that PPAR-γ overexpression alleviates inflammation and fibrosis while PCK1 overexpression exacerbates them.
bioRxiv · Aug 11, 2026 · PreprintMolecular Biology