Suboptimal phenotypic reliability impedes reproducible human neuroscience
Aki Nikolaidis, Andrew A. Chen, Xiaoning He, Russell Taki Shinohara, Joshua T Vogelstein, Michael Peter Milham, Haochang Shou
Simulations and neuroimaging analyses argue that unreliable clinical and cognitive phenotypes, not only noisy fMRI, cap biomarker discovery; aggregating across raters or repeated measures beats enlarging samples.
bioRxiv · Jul 22, 2022 · PreprintNeuroscience