Extracellular DDR1 targeting remodels collagen-rich tumor stroma and local immunity
Xuan Huang, Xinlin Liu, Litao Huang, Guangjun Jing, Kudelaidi Kuerban, Menghan Cai, Qing Yue, Mei Yu, Shanglin Yang, Yi Zhun Zhu, Li Ye
This study develops DDR1-targeting nanobodies that remodel collagen-rich tumor stroma and immune compartments, enhancing tumor control without direct tumor-cell inhibition.
bioRxiv · Nov 3, 2026 · PreprintImmunology